AstraZeneca, Pharmacyclics and Janssen team up on Imbruvica and MEDI4736 combination trial

4 November 2014

Anglo-Swedish drug major AstraZeneca (LSE: AZN) and US health care giant Johnson & Johnson’s (NYSE: JNJ) Europe-based subsidiary Janssen are to collaborate on a clinical trial to evaluate the efficacy and safety of AstraZeneca’s MEDI4736 in combination with Imbruvica (ibrutinib).

MEDI4736 is an investigational anti-PD-L1 immune checkpoint inhibitor, and Imbruvica is an oral Bruton’s tyrosine kinase inhibitor, co-developed by Pharmacyclics (Nasdaq: PCYC) and Janssen and commercialized outside the USA by Janssen affiliates.

The study will assess the MEDI4736-Imbruvica combination as a treatment for patients with hematological cancers including diffuse large B-cell lymphoma and follicular lymphoma, which are investigational uses for both compounds.

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