AstraZeneca eyes KESTREL as EAGLE flops

10 December 2018

There was no good news from the results of AstraZeneca’s (LSE: AZN) Phase III EAGLE trial, although the fact that the failure did not seem that important was good news in itself.

Shares were undamaged by Friday’s announcement of the overall survival (OS) results, which showed that Imfinzi (durvalumab) as a monotherapy or with tremelimumab did not improve OS compared to standard-of-care chemotherapy recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) patients who experienced disease progression following platinum-based chemotherapy, regardless of PD-L1 tumor status.

Sean Bohen, executive vice president, global medicines development and chief medical officer, said: “The prognosis for recurrent or metastatic HNSCC is very poor and new treatments for this group of cancers are urgently needed.

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