ASCO: Positive data on Celldex' Rintega in glioblastoma

1 June 2015

US immunotherapy specialists Celldex Therapeutics (Nasdaq: CLDX) has presented positive results from its randomized, double-blind Phase II study of Rintega (rindopepimut) in patients with EGFRvIII-positive, recurrent glioblastoma at the 2015 American Society of Clinical Oncology (ASCO) annual meeting in Chicago.

The primary endpoint of the study, progression-free survival at six months (PFS6) was met, and a clear advantage was demonstrated across multiple, clinically important endpoints including overall survival (OS), long-term progression-free survival, objective response rate (ORR) and need for steroids.

The data were presented in an oral presentation by David Reardon, Clinical Director, Center for Neuro-Oncology, Dana-Farber Cancer Institute; Associate Professor of Medicine, Harvard Medical School; and President of the Society for Neuro-Oncology, as well as the lead investigator of the ReACT study.

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