ASCO 2024: Positive Phase III results for Sanofi’s Sarclisa could challenge Darzalex
French pharma major Sanofi (Euronext: SAN) released positive new data from the IMROZ Phase III study at the American Society of Clinical Oncology (ASCO) annual meeting.
These demonstrated that the firm’s Sarclisa (isatuximab) in combination with standard-of-care bortezomib, lenalidomide and dexamethasone (VRd) followed by Sarclisa-Rd (the IMROZ regimen) significantly reduced the risk of disease progression or death by 40%, compared to VRd followed by Rd in patients with newly diagnosed multiple myeloma (NDMM) not eligible for transplant.
While Johnson & Johnson's Darzalex (daratumumab) has established itself as a dominant anti-CD38 therapy for multiple myeloma (MM), Sanofi looks poised to challenge that position. Both drugs are CD38 inhibitors. In 2023, Darzalex generated $9.74 billion sales.
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