Array halts Phase III binimetinib trial in ovarian cancer

4 April 2016
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US biotech firm Array BioPharma (Nasdaq: ARRY) says it has decided to discontinue the MILO study, a Phase III trial of binimetinib for the treatment of patients with low-grade serous ovarian cancer.

The company's shares were down 7.12% to $2.74 in pre-market trading on Friday, when the announcement was made, but ended the day up 1.7% at $3.00

The decision to stop the study was made after a planned interim analysis showed that the Hazard Ratio for Progression Free Survival (PFS) crossed the predefined futility boundary.  Top-line results from the study had been expected in 2017.

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