UPDATE: Ardelyx regains tenapanor and related NHE3 portfolio rights from AstraZeneca

3 June 2015

US biopharma company Ardelyx (Nasdaq: ARDX) says it has entered into a termination agreement with Anglo-Swedish pharma major AstraZeneca (LSE: AZN), such that all the rights to Ardelyx' portfolio of NHE3 inhibitors, including its lead product candidate, tenapanor, are returned to Ardelyx.

The decision comes about a month after Ardelyx announced that tenapanor failed to meet the primary endpoint of a Phase IIa clinical trial in patients with Stage 3 chronic kidney disease with type 2 diabetes mellitus and albuminuria (The Pharma Letter May 6). Under the terms of the agreement, AstraZeneca was obliged to communicate to Ardelyx on or before June 29, whether it will continue the development of tenapanor.

Ardelyx will pay AstraZeneca $25 million under termination terms

This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Try before you buy

Free

7 day trial access

Take a Free Trial

All the news that moves the needle in pharma and biotech
Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
Receive The Pharma Letter daily news bulletin, free forever.

Become a subscriber

£820

Or £77 per month

Subscribe Now

Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
Daily roundup of key events in pharma and biotech.
Monthly in-depth briefings on Boardroom appointments and M&A news.
Choose from a cost-effective annual package or a flexible monthly subscription

The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK