Arcus and Gilead present promising data for TIGIT inhibitor
Results from the ARC-10 Phase III study of Arcus Biosciences (NYSE: RCUS) and Gilead Sciences’ (Nasdaq: GILD) domvanalimab and zimberelimab combination therapy indicate a significant reduction in mortality risk for patients with certain advanced lung cancers.
The data, shared at this week’s Society for Immunotherapy of Cancer annual meeting, could help reignite interest in TIGIT inhibition, after several setbacks in the field.
The ARC-10 study evaluated the combination of domvanalimab, an Fc-silent TIGIT monoclonal antibody, with zimberelimab, a checkpoint blocker, against zimberelimab alone and standard chemotherapy in people with advanced non-small cell lung cancer (NSCLC).
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