The chief executive of UK biotech Antisoma, Glyn Edwards, has stepped down in the wake of the recent late-stage failures in the company's clinical pipeline.
Finance director Eric Dodd has also walked, according to a Reuters report, although he is continuing to advise Antisoma on strategic options, which could include the sale of the company.
In January, Antisoma's lead drug candidate AS1413 (amonafide malate) bombed in a Phase III trial involving patients with secondary acute myeloid leukemia after the study missed its primary endpoint, an improvement the complete remission rate with or without recovery of normal blood counts.
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