Antisense setback for partners Biogen and Ionis

17 May 2024

American biopharma company Biogen (Nasdaq: BIIB) is to pull the plug on two antisense oligonucleotide (ASO) programs.

In a statement, the firm said it would stop development of BIIB105, an ASO for amyotrophic lateral sclerosis (ALS), based on top-line results from the Phase I/II ALSpire study.

Biogen said it would also not exercise its option to license and lead development of BIIB121, an ASO designed to treat the rare genetic condition Angelman syndrome.

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