Antibody-drug conjugates taking center stage in oncology

13 March 2023

An analysis of the recent investment activity in antibody–drug conjugates (ADCs) prior to Pfizer's (NYSE: PFE) newly-announced $43 billion takeover of Seagen (Nasdaq: SGEN).

An ADC is typically composed of a monoclonal antibody (MAb) covalently attached to a cytotoxic drug (payload) via a chemical linker (which helps to increase tumor specificity and reduce off-target effects. In 2021, the ADC market was worth $4 billion and is forecast to rise to $13.13 billion by 2030, delivering a CAGR 2021-2030 of 14.12% (Figure 1).

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