Amgen's Kyprolis doubles progression-free survival in head-to-head against Velcade

2 March 2015

USA-based biotech firm Amgen (Nasdaq: AMGN) and its subsidiary Onyx Pharmaceuticals have announced the interim results of a Phase III head-to-head trial evaluating Kyprolis (carfilzomib) and dexamethasone versus Velcade (bortezomib) and dexamethasone.

The ENDEAVOR trial evaluated Kyprolis and Velcade with low doses of dexamethasone in treating relapsed multiple myeloma, and found that it met its primary endpoint of progression-free survival.

Patients with relapsed multiple myeloma treated with Kyprolis lived twice as long (18.7 months versus 9.4 months) without their disease worsening, demonstrating statistical and clinical superiority over Velcade.

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