Amgen gives up on omecamtiv mecarbil

23 November 2020

US biotech major Amgen (Nasdaq: AMGN) has returned all development and commercialization rights for omecamtiv mecarbil and AMG 594 to Cytokinetics (Nasdaq: CYTK).

Omecamtiv mecarbil, an investigational selective cardiac myosin activator, was studied in GALACTIC-HF, a Phase III trial in patients with chronic heart failure with reduced ejection fraction (HFrEF), and AMG 594, a new mechanism selective cardiac troponin activator, is in Phase I development for HFrEF and other types of heart failure.

Results from the omecamtiv mecarbil trial demonstrated an 8% relative risk reduction on the primary composite endpoint of heart failure or cardiovascular death, compared with placebo.

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