Ambrx and NovoCodex anti-HER2 ADC meets endpoint in breast cancer trial

2 March 2023

USA-based Ambrx Biopharma (NYSE: AMAM) and partner NovoCodex Biopharmaceuticals have announced an update on ACE-Breast-02, a Phase III breast cancer trial.

Ambrx’s ARX788, an anti-HER2 antibody drug conjugate (ADC), has met its pre-specified interim primary efficacy endpoint with statistical significance, demonstrating a greater progression free survival (PFS) benefit compared to the active control.

The drug is in development for the treatment of HER2 positive patients with locally advanced or metastatic breast cancers in China. In this trial, patients were given the drug who have been previously treated with taxane and trastuzumab.

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