Alnylam reports positive vutrisiran data in hATTR amyloidosis with polyneuropathy at 18 months

28 October 2021
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US biotech Alnylam Pharmaceuticals (Nasdaq: ALNY) has announced new data from the HELIOS-A Phase III study of vutrisiran, an investigational RNAi therapeutic in development for the polyneuropathy associated with hereditary transthyretin-mediated (hATTR) amyloidosis.

This study met all secondary endpoints measured at 18 months, including statistically-significant improvements in neuropathy as measured by the modified neuropathy impairment score, quality of life, gait speed, nutritional status and overall disability, relative to external placebo data from the APOLLO Phase III study of patisiran.

Continuation of success seen at nine months

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