Alnylam presents new lumasiran data at ASN Kidney Week
US RNAi therapy specialist Alnylam Pharmaceuticals (Nasdaq: ALNY) saw its rise 4.2% to $168.29 on Friday, after it presented new 24-month results from the ILLUMINATE-C Phase III open-label study of lumasiran in patients with advanced primary hyperoxaluria type 1 (PH1), an inherited rare disease, at the American Society of Nephrology (ASN) Kidney week 2023.
The findings demonstrate that in lumasiran-treated PH1 patients with severe renal impairment, including those on dialysis, reductions in plasma oxalate were maintained through 24 months of treatment.
The overproduction of oxalate – an unneeded end-product of the metabolism – in the liver can lead to the formation of painful, recurrent kidney stones and nephrocalcinosis, which can ultimately progress to kidney failure.
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