Alnylam presents new lumasiran data at ASN Kidney Week

6 November 2023

US RNAi therapy specialist Alnylam Pharmaceuticals (Nasdaq: ALNY) saw its rise 4.2% to $168.29 on Friday, after it presented new 24-month results from the ILLUMINATE-C Phase III open-label study of lumasiran in patients with advanced primary hyperoxaluria type 1 (PH1), an inherited rare disease, at the American Society of Nephrology (ASN) Kidney week 2023.

The findings demonstrate that in lumasiran-treated PH1 patients with severe renal impairment, including those on dialysis, reductions in plasma oxalate were maintained through 24 months of treatment.

The overproduction of oxalate – an unneeded end-product of the metabolism – in the liver can lead to the formation of painful, recurrent kidney stones and nephrocalcinosis, which can ultimately progress to kidney failure.

This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Try before you buy

Free

7 day trial access

Take a Free Trial

All the news that moves the needle in pharma and biotech
Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
Receive The Pharma Letter daily news bulletin, free forever.

Become a subscriber

£820

Or £77 per month

Subscribe Now

Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
Daily roundup of key events in pharma and biotech.
Monthly in-depth briefings on Boardroom appointments and M&A news.
Choose from a cost-effective annual package or a flexible monthly subscription

The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK