Aldeyra's dry eye data sends shares into orbit

27 September 2018

Shares in US drugmaker Aldeyra Therapeutics (NASDAQ: ALDX) closed up 35% on Wednesday due to positive results from its Phase IIb clinical trial of topical ocular reproxalap in patients with dry eye disease.

The trial investigated 0.1% and 0.25% concentrations of reproxalap topical ophthalmic solution versus vehicle. Relative to patients treated with vehicle, patients given the 0.25% concentration of reproxalap had statistically-significant and clinically-relevant reductions in the four-symptom ocular dryness score and the overall ocular discomfort symptom score.

Symptom improvement greater than that of vehicle was consistently observed across all measures, and activity versus vehicle was demonstrated as early as two weeks.

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