Adding Lynparza and Imfinzi to chemo and bevacizumab aids PFS, trial shows

5 April 2023

Positive high-level results from a planned interim analysis of the DUO-O Phase III trial have been presented by Anglo-Swedish drugmaker AstraZeneca (LSE: AZN), which was subsequently trading 2% higher by lunchtime Wednesday.

The results show that adding AstraZeneca’s drugs Lynparza (olaparib) and Imfinzi (durvalumab) to chemotherapy and bevacizumab led to a statistically-significant and clinically-meaningful improvement in progression-free survival (PFS) in newly-diagnosed patients with advanced high-grade epithelial ovarian cancer without tumor BRCA mutations.

"It will be important to understand the key secondary endpoints as well as data for relevant subgroups"Patients were treated with Imfinzi in combination with chemotherapy and bevacizumab followed by Imfinzi, Lynparza and bevacizumab as maintenance therapy.

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