Aclaris slumps as Phase IIa study of oral zunsemetinib disappoints
Shares of Aclaris Therapeutics (Nasdaq: ACRS) closed down almost 45% at $7.07 yesterday, as the company said its zunsemetinib did not meet its primary and secondary efficacy endpoints in a Phase IIa study evaluating the investigational drug in patients with moderate to severe hidradenitis suppurativa.
Hidradenitis suppurativa, also known as acne inversa, is a chronic skin condition featuring painful nodules and abscesses under the skin that can enlarge and drain pus.
The only drug currently approved to treat the disease is AbbVie’s (NYSE: ABBV) Humira (adalimumab), but Novartis (NOVN: VX) is moving to get its interleukin (IL)-17 therapy Cosentyx (secukinumab) approved as an option.
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