AbbVie and Cugene collaborate on autoimmune diseases

17 May 2022

US pharma major AbbVie (NYSE: ABBV) has announced an exclusive worldwide license option agreement with clinical-stage biotech Cugene for CUG252, a potential best-in-class Treg-selective interleukin (IL)-2 mutein, as well as other novel IL-2 muteins, for the potential treatment of autoimmune and inflammatory diseases.

Selective IL-2 muteins have the potential to represent a major advancement in the standard of care for patients with autoimmune and inflammatory diseases. Cugene's lead candidate, CUG252, is an engineered IL-2 mutein designed to selectively activate and expand immune-suppressive Treg cells while reducing undesired IL-2 activity on other IL-2 receptor expressing cells for the treatment of autoimmune diseases. CUG252 is currently in a Phase I study in healthy volunteers.

Financial and other terms of the deal

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