89bio looks for lead in FGF21 with Phase III trial imminent

26 August 2022

Shares in liver and cardio-metabolic specialist 89bio (Nasdaq: ETNB) were up 5% ahead of the opening bell on Friday, following positive Phase II results from the ENTRIGUE study.

The San Franciscan firm is developing pegozafermin, a specifically engineered glycoPEGylated analog of fibroblast growth factor 21 (FGF21), as an option for severe hypertriglyceridemia (SHG).

Data showing the proof-of-concept trial met its primary efficacy endpoint will be presented at the annual meeting of the European Society of Cardiology in the coming days.

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