Pfizer's Rituxan/MabThera biosimilar looks promising

24 January 2018

US pharma giant Pfizer (NYSE: PFE) could be yet another contender in the growing number of biosimilar copies of Roche’s (ROG: SIX) blockbuster cancer drug Rituxan/MabThera (rituximab).

Pfizer today announced that REFLECTIONS B3281006, a comparative safety and efficacy study of PF-05280586 versus MabThera(rituximab-EU), met its primary endpoint. The trial demonstrated equivalence in overall response rate (ORR) for the first-line treatment of patients with CD20-positive, low tumor burden, follicular lymphoma.

Rituxan/MabThera is indicated for the treatment of patients with certain types of CD20-positive non-Hodgkin’s lymphoma; CD20-positive chronic lymphocytic leukemia; rheumatoid arthritis; granulomatosis with polyangiitis and microscopic polyangiitis; and other region-specific indications.

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