Amgen and Allergan's biosimilar shows equivalence to Avastin in NSCLC

23 September 2015

US biotech major Amgen (Nasdaq: AMGN) and Allergan (NYSE: AGN) has announced that the biosimilar ABP 215 met its primary and secondary endpoints in a Phase III trial.

The study evaluated the safety and efficacy of ABP 215 compared to Avastin (bevacizumab) from Genentech, a subsidiary of Roche (SIX: ROG) in advanced non-squamous non-small cell lung cancer.

ABP 215 showed clinical equivalence of the biosimilar to bevacizumab, and it also had comparable safety and immunogenicity. Secondary endpoint results were consistent with the primary finding and included risk difference of objective response rates, duration of response and progression-free survival.

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