Positive new Phase III results for Padcev and Keytruda in bladder cancer

22 September 2023

US biotech Seagen (Nasdaq: SGEN) and Japanese partner Astellas Pharma (TYO:4503) today announced positive top-line results from the much awaited Phase III EV-302 clinical trial (also known as KEYNOTE-A39). The news lifted Seagen's shares 3.3% to $213.64

The study investigated Padcev (enfortumab vedotin-ejfv) in combination with Keytruda (pembrolizumab) versus chemotherapy in patients with previously untreated locally advanced or metastatic urothelial cancer (la/mUC), a form of bladder cancer that has spread to surrounding organs or muscles, or other parts of the body.

The EV-302 trial enrolled patients with previously untreated la/mUC who were eligible for cisplatin- or carboplatin-containing chemotherapy regardless of PD-L1 status.

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