Novartis turns back on Pliant deal in NASH

24 February 2023

Swiss pharma giant Novartis (NOVN: VX) has ended its collaboration and license agreement with Californian biotech Pliant Therapeutics (Nasdaq: PLRX).

This has come about since Novartis made the decision to divest its clinical non-alcoholic steatohepatitis (NASH) assets as part of its new strategy focusing on a limited number of therapeutic areas.

The lead asset in the collaboration with Pliant was PLN-1474, a small molecule selective inhibitor of integrin αvß1, which is being developed for the treatment of liver fibrosis associated with NASH, while the deal also provided for an early research program for up to three additional integrin targets.

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