NewLink to review IDO blocker program following Incyte failure

9 April 2018

Shares in NewLink Genetics (Nasdaq: NLNK) plunged on Friday as the firm announced a review of its clinical programs.

The announcement followed shortly after Incyte (Nasdaq: INCY) revealed the failure of its ECHO-301 melanoma trial, wiping billions from the value of the company. Incyte has been evaluating the IDO pathway inhibitor epacadostat in combination with Merck & Co’s (NYSE: MRK) Keytruda (pembrolizumab).

NewLink’s IDO blocker indoximod is being developed in several indications, and the firm says it has a differentiated mechanism of action which could prove successful.

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