Lynparza lands AstraZeneca and Merck milestone in ovarian cancer

27 June 2018

Development and commercialization partners AstraZeneca (LSE: AZN) and Merck & Co (NYSE: MRK) have clocked up a potentially important milestone with Lynparza (olaparib) that could expand the drug's reach considerably.

Their asset is the first PARP inhibitor to show a significant and clinically-impactful improvement in progression-free survival in the first-line maintenance setting for women with BRCA-mutated ovarian cancer.

Based on this and other findings from the Phase III SOLO-1 trial on Lynparza, UK-based AstraZeneca and Merck, which is known as MSD outside North America, plan to initiate discussions with health authorities regarding regulatory submissions. Full data from the trial are expected to be presented later this year.

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