Lilly's lead Alzheimer's candidate disappoints in Phase III study

23 November 2016

In another disappointment for Alzheimer’s sufferers, and notably for US pharma major Eli Lilly (NYSE: LLY), disappointing late-stage study results with its lead drug candidate for the condition have been revealed. Lilly’s shares fell as much as 14% on the news, and were down 12.5% at $66.51 mid-morning.

Lilly today announced that solanezumab did not meet the primary endpoint in the EXPEDITION3 clinical trial, a Phase III study of solanezumab in people with mild dementia due to Alzheimer's disease (AD), adding to failures in two previous studies.

Patients treated with solanezumab did not experience a statistically significant slowing in cognitive decline compared to patients treated with placebo (p=.095), as measured by the ADAS-Cog14 (Alzheimer's Disease Assessment Scale-Cognitive subscale).

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