Millions of people affected by Alzheimer’s disease were dealt a cruel blow on Thursday as the developers of aducanumab, a much-anticipated late stage candidate, announced the discontinuation of Phase III testing.
USA-based Biogen (Nasdaq: BIIB) has been developing the biologic therapy in collaboration with Tokyo’s Eisai (TYO: 4523). Shares in Biogen plummeted by around a quarter ahead of the opening bell in New York.
An independent analysis suggested the trial, which was testing aducanumab against mild cognitive impairment due to Alzheimer’s disease and mild Alzheimer’s disease dementia, would not meet its primary efficacy endpoint.
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