HD hopes revived by Roche reappraisal of tominersen

19 January 2022

A novel antisense medicine, previously dropped by Roche (ROG: SIX), is to be picked up again in the hope of making a breakthrough in Huntington's disease (HD).

Out-licensed to the Swiss firm in 2017 by American biotech Ionis Pharmaceuticals (Nasdaq: IONS), tominersen will be tested in a new Phase II trial.

The surprise decision comes after an exploratory post-hoc analysis suggested the therapy may benefit younger adults with lower disease burden.

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