Futility leads Merrimack to drop Phase II MM-121 study in NSCLC

19 October 2018

Shares of US drugmaker Merrimack Pharmaceuticals (Nasdaq: MACK) were down 30.23% at $3.60 in pre-market trading today, after it announced the termination of the SHERLOC study.

This was the company's randomized, open-label Phase II clinical trial evaluating MM-121 (seribantumab) in combination with docetaxel in patients with heregulin positive non-small cell lung cancer. Merrimack said the data demonstrated that the addition of MM-121 to docetaxel did not improve progression free survival over docetaxel alone in this patient population.

Based on the results, Merrimack is implementing a comprehensive review of its drug candidate pipeline, including assessing the impact of these results on the continued development of MM-121. Merrimack will provide an update on its pipeline and the results of its portfolio review on its third quarter 2018 financial results call on November 7, 2018.

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