ASCO 2024: MOTION Phase III data demonstrate robust efficacy, says Deciphera
USA-based tumor drug resistance specialist Deciphera Pharmaceuticals (Nasdaq: DCPH) today announced results from the company’s MOTION pivotal Phase III study of vimseltinib in patients with Tenosynovial Giant Cell Tumor (TGCT) in an oral presentation at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.
The study met its primary endpoint in the intent-to-treat (ITT) population demonstrating statistically-significant and clinically-meaningful improvement versus placebo in overall response rate (ORR) at Week 25 based on IRR per RECIST v1.1.
In the ITT population, the ORR at Week 25 was 40% (95% CI: 29%, 51%) for the vimseltinib arm and 0% (95% CI: 0%, 9%) for the placebo arm resulting in a response difference (vimseltinib versus placebo) of 40% (95% CI: 29%, 51%) (p<0.0001).
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