Arcus inks deal with AstraZeneca on ccRCC candidates
US clinical-stage biotech Arcus Biosciences (NYSE: RCUS) has entered into a clinical trial collaboration with AstraZeneca (LSE: AZN) on renal cancer treatments.
The companies will evaluate casdatifan (AB521), Arcus’s investigational HIF-2a inhibitor, in combination with volrustomig, the UK pharma major’s investigational PD-1/CTLA-4 bispecific antibody, in patients with clear cell renal cell carcinoma (ccRCC).
“We believe casdatifan has best-in-class potential, based on the observed PK and PD profiles and the emerging clinical data from our ARC-20 study in patients with ccRCC,” said Terry Rosen, chief executive of Arcus, noting that “this agreement will enable Arcus and AstraZeneca to collaborate and assess the potential for the novel combination of casdatifan with volrustomig to improve outcomes for patients with ccRCC.”
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