All smiles at GRIN over radiprodil prospects

26 February 2025

Neurodevelopmental disorders company GRIN Therapeutics, an affiliate of the Blackstone Life Sciences portfolio company Neurvati Neurosciences, has announced a major milestone.

The US Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to radiprodil, the company’s investigational, potent negative allosteric modulator selectively targeting the N-methyl-D-aspartate receptor subtype 2B, for the treatment of seizures associated with GRIN-related neurodevelopmental disorder with gain-of-function (GoF) mutations.

This designation was supported by positive data from the Phase Ib Honeycomb study in pediatric patients with confirmed GoF mutations across GRIN genotypes.

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