Aligos Phase II results for ALG-055009 in MASH fail to impress
California-based liver and viral disease specialist Aligos Therapeutics (Nasdaq: ALGS) has announced positive top-line results from the Phase IIa HERALD study of ALG-055009, a thyroid hormone receptor beta (THR-β) agonist, in metabolic-dysfunction associated steatohepatitis (MASH) subjects.
However, investors were not impressed, sending the stock tumbling more than 28% to $10.18 by close of trading yesterday.
HERALD is a randomized, double-blind, placebo-controlled trial that enrolled 102 subjects with presumed MASH and stage 1-3 liver fibrosis (F1-F3). Subjects were randomized to receive one of four doses (0.3, 0.5, 0.7, 0.9mg) of ALG-055009 or placebo (~20 subjects/arm) given orally once daily for 12 weeks.
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