SJG-136 achieves partial response in OC patient
French drugmaker Ipsen and privately-held UK-based Spirogen presented promising final results from a Phase I trial of their DNA sequence-recognizing minor groove binder, SJG-136, at the American Society of Clinical Oncology annual meeting in Chicago.
The small-molecule agent, which spans six base pairs of DNA, is currently undergoing clinical development in refractory solid tumors and hematological malignancies with the US National Cancer Institute under a Cooperative Research and Development Agreement.
The Phase I results show that SJG-136 administered three times a day at 30mcg/m2/day (recommended Phase II dosing) resulted in confirmed partial response as defined by RECIST criteria in one out of six patients evaluated and a second unconfirmed partial response. Of these two patients, one had ovarian cancer and the second a poorly differentiated ovarian carcinoma.
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