Roche's atezolizumab shrank tumors in specific type of bladder cancer

14 July 2015

Swiss drug major Roche (ROG: SIX) saw its shares edge up 1.6% on Monday, after it released encouraging results with its investigational drug atezolizumab.

Roche, and its subsidiary Genentech, announced that in the IMvigor 210 study, atezolizumab (MPDL3280A; anti-PDL1) shrank tumors (objective response rate, ORR, the primary end point of this Phase II study) in people with locally advanced or metastatic urothelial bladder cancer (UBC) who had progressed on initial treatment (second-line or later).

High amounts of PD-L1 (programmed death ligand-1) expression by a person’s cancer correlated with increased response to the medicine. Adverse events were consistent with what has been previously observed for atezolizumab.

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